Welcome! Our laboratory studies the mechanisms underlying complex neurodegenerative diseases, including Alzheimer’s Disease, Parkinson’s Disease and Frontotemporal Lobar Degeneration (FTLD). Our techniques range from cellular neurobiology to population studies and clinical trials. We’re interested in identifying new disease-related biological pathways, evaluating new experimental therapeutics, and developing new disease-specific biomarkers.
News
Latest Publications
Do AN, Song S, Ali M, Timsina J, Wang L, Western D, Liu M, Sanford J, Rosende-Roca M, Boada M, Puerta R, Wilson EN, Ruiz A, Pastor P, ADNI, Wyss-Coray T & Cruchaga C “CSF proteomic profiling with amyloid and tau pathology identifies distinctive sex-specific alteration of multiple proteins involved in Alzheimer’s disease” Alzheimer’s & Dementia. 22(1):e71063 (2026). [PubMed]
Winer, JR, Vossler H, Young CB, Smith V, Romero A, Shahid-Besanti M, Abdelnour C, Wilson EN, Anders D, Pacheco Morales A, Andreasson KI, Yutsis MV, Henderson VW, Davidzon GA, Mormino EC, Poston KL “18F-PI-2620 Tau PET is associated with cognitive and motor impairment in Lewy body disease” Brain Communications. 7(1) (2025). [PubMed]
Oh HS, Urey DY, Karlsson L, Zhu Z, Shen Y, Farinas A, Timsina J, Duggan MR, Chen J, Guldner IH, Morshed N, Yang C, Western D, Ali M, Le Guen Y, Trelle A, Herukka SK, Rauramaa T, Hiltunen M, Lipponen A, Luikku AJ, Poston KL, Mormino E, Wagner AD, Wilson EN, Channappa D, Leinonen V, Stevens B, Ehrenberg AJ, Gottesman RF, Coresh J, Walker KA, Zetterberg H, Bennett DA, Franzmeier N, Hansson O, Cruchaga C, Wyss-Coray T “A Cerebrospinal Fluid Synaptic Protein Biomarker for Prediction of Resilience Versus Decline in Alzheimer’s Disease” Nature Medicine. 31:1592-1603 (2025). [PubMed]
Grandke F, Fehlmann T, Kern F, Gate DM, Wolff TW, Leventhal O, Channappa D, Hirsh P, Wilson EN, Meese E, Liu C, Shi Q, Flotho M, Lil Y, Chen C, Yu Y, Xu J, Junkin M, Wang Z, Wu T, Liu L, Hou Y, Andreasson KI, Gansen JS, Mass E, Poston KL, Wyss-Coray T, Keller A “A single-cell atlas to map sex-specific gene-expression changes in blood upon neurodegeneration” Nature Communications. 16 (1): 1965 (2025).






