Welcome! Our laboratory studies the mechanisms underlying complex neurodegenerative diseases, including Alzheimer’s Disease, Parkinson’s Disease and Frontotemporal Lobar Degeneration (FTLD). Our techniques range from cellular neurobiology to population studies and clinical trials. We’re interested in identifying new disease-related biological pathways, evaluating new experimental therapeutics, and developing new disease-specific biomarkers.
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Van Meter TE, Wilson EN, Elahi F, Rissman RA, Lago AL, Faber K, Gauthreaux K, Osorio R, Perkins M, Gray N, Morris J, Liu A, Stockwell H, Kukull W, Wilson R, Wingo TS, Kanaan NM, Russ K, Wilcock D, Biber SA, Bekris LM, Karikari TK. Pre-analytical guidelines for blood and CSF Biomarkers 2025: Recommendations from the NACC ADRC Biofluid Biomarker Best Practices Workgroup. Alzheimers Dement. 2026 May;22(5):e71252. doi: 10.1002/alz.71252. PMID: 42080228; PMCID: PMC13137281. [PubMed]
Bettcher BM, Ren S, Wang Y, Carlson NE, Lippitt WL, McConnell BV, Wilson EN, Shapiro ALB, Coughlan C, Carlisle TC, Unger JR, Cook GG, Bengtson K, Gorla L, Ueberheide BM, Kanshin E, Potter H, Schulz L, Frazer-Abel A, Pelak VS. Relation of blood-based inflammation conditional networks to key immune health status and Alzheimer's biomarkers in aging adults. Neurobiol Aging. 2026 May 9;166:14-28. doi: 10.1016/j.neurobiolaging.2026.05.001. Epub ahead of print. PMID: 42139770. [PubMed]
Winer JR, Plastini MJ, Romero A, Vossler H, Sai I, Channappa D, Abdelnour C, Shahid-Besanti M, Wilson EN, Oh HS, Young CB, Trelle A, Yutsis M, Sha SJ, Ramirez V, Taylor R, Younes K, Wyss-Coray T, Greicius MD, Henderson VW, Wagner AD, Poston KL, Mormino EC. Effects of α-synuclein pathology on synaptic dysfunction and clinical outcomes in normal aging. Alzheimers Dement. 2026 May;22(5):e71455. doi: 10.1002/alz.71455. PMID: 42071168; PMCID: PMC13135916. [PubMed]
Trelle AN, Cody KA, Nguyen TT, Winer JR, Weiss S, Sai I, Ward T, Cheng G, Channappa D, Mendiola J, Al-Rajhi A, Raghuraman K, Sha SJ, Wilson EN, Wyss-Coray T, Maecker HT, Wagner AD, Mormino EC. Plasma proteomic signatures of preclinical Alzheimer's disease in clinically unimpaired older adults. Mol Neurodegener. 2026 Apr 24. doi: 10.1186/s13024-026-00941-5. Epub ahead of print. PMID: 42032756. [PubMed]






